Giuseppe Verdile Selected Research

latrepirdine (dimebon)

1/2016	The Effects of Latrepirdine on Amyloid-β Aggregation and Toxicity.
12/2013	Latrepirdine: molecular mechanisms underlying potential therapeutic roles in Alzheimer's and other neurodegenerative diseases.
1/2012	Latrepirdine (dimebon) enhances autophagy and reduces intracellular GFP-Aβ42 levels in yeast.

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Giuseppe Verdile Research Topics

Disease

45	Alzheimer Disease (Alzheimer's Disease) 01/2022 - 09/2003
13	Cognitive Dysfunction 01/2022 - 11/2006
9	Dementia (Dementias) 01/2022 - 04/2008
6	Insulin Resistance 01/2022 - 01/2015
6	Type 2 Diabetes Mellitus (MODY) 11/2020 - 12/2005
5	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2016 - 11/2006
3	Amyloid Plaque 01/2022 - 01/2018
3	Neuroblastoma 01/2021 - 05/2004
3	Atrophy 01/2018 - 12/2015
3	Inflammation (Inflammations) 01/2017 - 12/2005
3	Hypoxia (Hypoxemia) 07/2015 - 01/2013
2	Parkinson Disease (Parkinson's Disease) 12/2013 - 11/2006
2	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 12/2013 - 11/2006
2	Neoplasms (Cancer) 01/2011 - 02/2008
1	Disease Progression 01/2021
1	Neuroinflammatory Diseases 01/2019
1	Necrosis 01/2019
1	Pathologic Processes 01/2019
1	Glucose Intolerance 12/2017
1	Hyperglycemia 12/2017
1	Traumatic Brain Injuries (Traumatic Brain Injury) 05/2016
1	Brain Injuries (Brain Injury) 12/2015
1	Mitochondrial Diseases (Mitochondrial Disease) 01/2015
1	Nervous System Diseases (Neurological Disorders) 01/2015
1	Frontotemporal Dementia (Semantic Dementia) 10/2014
1	Stroke (Strokes) 10/2014
1	Brain Ischemia (Cerebral Ischemia) 10/2014
1	Hidradenitis Suppurativa 02/2014
1	Dilated Cardiomyopathy (Cardiomyopathy, Congestive) 02/2014
1	Pick Disease of the Brain (Pick's Disease) 02/2014
1	Proteostasis Deficiencies 01/2012
1	Coronary Artery Disease (Coronary Atherosclerosis) 12/2009
1	Hydrocephalus (Hydrocephaly) 02/2008
1	Sarcoma (Soft Tissue Sarcoma) 01/2008
1	Atherosclerosis 11/2006

Drug/Important Bio-Agent (IBA)

17	Amyloid (Amyloid Fibrils)IBA 01/2022 - 01/2011
13	Proteins (Proteins, Gene)FDA Link 01/2021 - 10/2004
10	Amyloid beta-PeptidesIBA 01/2020 - 10/2004
7	Biomarkers (Surrogate Marker)IBA 01/2022 - 08/2008
6	Apolipoproteins E (ApoE)IBA 02/2021 - 12/2009
6	Testosterone (Sustanon)FDA Link 01/2017 - 06/2008
6	Luteinizing Hormone (Lutropin)FDA LinkGeneric 11/2015 - 05/2004
5	Glucose (Dextrose)FDA LinkGeneric 11/2020 - 01/2015
5	CholesterolIBA 01/2020 - 04/2006
5	Peptides (Polypeptides)IBA 01/2019 - 01/2011
5	Insulin (Novolin)FDA Link 01/2017 - 04/2006
4	ApolipoproteinsIBA 06/2019 - 12/2009
4	Flavin-Adenine Dinucleotide (FAD)IBA 01/2016 - 02/2008
3	latrepirdine (dimebon)IBA 01/2016 - 01/2012
3	Biological ProductsIBA 01/2015 - 01/2011
3	GonadotropinsIBA 04/2008 - 05/2004
2	Protein AggregatesIBA 01/2022 - 01/2012
2	3,8-dihydroxy-6H-dibenzo(b,d)pyran-6-oneIBA 01/2022 - 10/2021
2	Microtubule-Associated Proteins (Microtubule-Associated Protein 2)IBA 01/2022 - 10/2014
2	PresenilinsIBA 01/2021 - 07/2015
2	Islet Amyloid PolypeptideIBA 01/2020 - 01/2017
2	LipidsIBA 01/2017 - 01/2015
2	tau Proteins (tau Protein)IBA 01/2017 - 12/2015
2	Amyloid Precursor Protein Secretases (beta-Secretase)IBA 01/2016 - 07/2015
2	Protein Isoforms (Isoforms)IBA 07/2015 - 10/2014
1	LuteolinIBA 01/2022
1	Omega-3 Fatty Acids (Omega 3 Fatty Acids)IBA 01/2021
1	Adenosine Triphosphate (ATP)IBA 01/2021
1	FlavonoidsIBA 01/2021
1	Presenilin-2IBA 01/2021
1	PolyphenolsIBA 01/2021
1	Heat-Shock Proteins (Heat-Shock Protein)IBA 11/2020
1	Amyloidogenic ProteinsIBA 01/2020
1	HDL LipoproteinsIBA 01/2020
1	InterleukinsIBA 01/2019
1	Interleukin-6 (Interleukin 6)IBA 01/2019
1	Nitric Oxide (Nitrogen Monoxide)FDA Link 01/2019
1	Nitric Oxide Synthase Type II (Inducible Nitric Oxide Synthase)IBA 01/2019
1	CytokinesIBA 01/2019
1	IronIBA 01/2018
1	CarbohydratesIBA 01/2017
1	Deoxyglucose (2 Deoxy D glucose)IBA 01/2016
1	Triglycerides (Triacylglycerol)IBA 01/2015
1	diadenosine pyrophosphate (AppA)IBA 02/2014
1	Neuroprotective AgentsIBA 12/2013
1	CarbazolesIBA 12/2013
1	Carbolines (Beta-Carbolines)IBA 12/2013
1	SynucleinsIBA 01/2012
1	Histamine (Histamine Dihydrochloride)FDA Link 01/2012
1	Carrier Proteins (Binding Protein)IBA 01/2011
1	cyclophilin BIBA 01/2011
1	Metalloproteases (Metalloproteinases)IBA 01/2011
1	Cyclophilin AIBA 01/2011
1	IntegrinsIBA 01/2011
1	SterolsIBA 01/2011
1	Caveolin 1IBA 01/2011
1	EP3 Subtype Prostaglandin E ReceptorsIBA 01/2008
1	CopperIBA 01/2008
1	Claudin-5IBA 01/2008
1	Non-Receptor Type 6 Protein Tyrosine PhosphataseIBA 01/2008
1	CaspasesIBA 01/2008
1	Reactive Oxygen Species (Oxygen Radicals)IBA 11/2006

Therapy/Procedure

3	Therapeutics 01/2020 - 01/2015
1	Cognitive Training 01/2017
1	Nursing Care 11/2006